Neomycin/Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension, USP – 5mL

Neomycin/Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension, USP – 5mL (Rx Only)

Brand: Bausch + Lomb
NDC: 24208-830-60
Product Type: Prescription Ophthalmic Suspension
Packaging: 5 mL sterile suspension in a 10 mL dropper bottle

Product Overview

Neomycin/Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension is a sterile, prescription-only anti-infective and anti-inflammatory combination eye drop used for the treatment of steroid-responsive inflammatory ocular conditions where there is a risk of bacterial infection.

Formulated by Bausch + Lomb, this multi-action ophthalmic solution combines:

• Neomycin sulfate (3.5 mg/mL) – a broad-spectrum aminoglycoside antibiotic

• Polymyxin B sulfate (10,000 units/mL) – an antibiotic effective against gram-negative bacteria

• Dexamethasone (0.1%) – a potent corticosteroid for reducing inflammation

This product provides convenient, effective, and synergistic treatment for managing inflammatory eye conditions with suspected or confirmed bacterial involvement.

Indications for Use

• Blepharitis (eyelid inflammation)

• Conjunctivitis (palpebral and bulbar)

• Keratitis

• Chronic anterior uveitis

• Corneal injury due to burns, chemicals, or foreign bodies

• Post-surgical inflammation with risk of infection

This combination is ideal when both anti-inflammatory and anti-bacterial actions are desired.

Clinical Benefits

• Dual-action formula: Combines antibiotics and corticosteroids in one solution

• Patient convenience: Single-drop therapy improves compliance

• Broad-spectrum coverage: Effective against many common ocular pathogens including Staphylococcus aureus, Escherichia coli, H. influenzae, Klebsiella/Enterobacter spp., Neisseria spp., and Pseudomonas aeruginosa

• Fast-acting relief: Reduces swelling, redness, and irritation while treating bacterial infection

Dosage & Administration

• Instill 1 to 2 drops into the conjunctival sac(s) every 4 to 6 hours

• In severe infections, dosing may be increased to every hour, then tapered as the condition improves

• Do not use beyond 10 days without monitoring intraocular pressure (IOP)

• Not more than 20 mL should be initially prescribed

Contraindications

• Viral eye infections (e.g., herpes simplex keratitis, varicella, vaccinia)

• Mycobacterial or fungal ocular infections

• Hypersensitivity to neomycin, polymyxin B, dexamethasone, or other formulation ingredients

Warnings & Precautions

• Not for injection or intraocular use

• Prolonged use may increase IOP, risk of glaucoma, or cause posterior subcapsular cataracts

• Use with caution in patients with glaucoma or thin corneas

• Potential for secondary infections due to immune suppression

• Avoid contact with dropper tip to prevent contamination

• Vision may be temporarily blurred after application – do not drive or operate machinery immediately after use

Use in Specific Populations

• Pregnancy & Nursing: Use only if benefits outweigh potential fetal or neonatal risks

• Pediatrics: Safety and efficacy not established under age 2

• Geriatrics: No significant differences in response compared to younger adults

Adverse Reactions

• Allergic sensitization, especially to neomycin

• Elevated intraocular pressure and optic nerve damage

• Cataract formation

• Keratitis, delayed healing, ulcerative keratitis

• Rare reports of Stevens-Johnson syndrome, headache, and conjunctival hyperemia

To report adverse events, contact Bausch + Lomb at 1-800-321-4576 or the FDA at www.fda.gov/medwatch.

How Supplied

• 5 mL sterile ophthalmic suspension in a white LDPE bottle with dropper tip and protective cap

• Supplied in a tamper-evident carton

• Storage: 15°C to 25°C (59°F to 77°F). Keep bottle upright and tightly closed.

Manufacturer Information

Manufactured by:
Bausch & Lomb Incorporated
Tampa, FL 33637 USA

Distributed by:
Bausch + Lomb, a division of
Bausch Health US, LLC
Bridgewater, NJ 08807 USA

Important Notes

• For topical ophthalmic use only

• Rx only – available by prescription from a licensed healthcare provider

• Do not share this medication with others, even if symptoms are similar

This product is a trusted solution for managing complex ocular conditions that require both antimicrobial and anti-inflammatory treatment. Prescribe confidently with Bausch + Lomb’s legacy of quality ophthalmic care.