Vuity (pilocarpine 1.25%)
AbbVie. One drop in each eye once daily, with an optional second dose 3 to 6 hours later.
LabelSpecialty Rx · Presbyopia
Presbyopia Eye Drops Vuity, Qlosi and VIZZ.
Three prescription drops narrow the pupil to extend depth of focus for near vision without readers.
1.25%pilocarpine in Vuity
0.4%pilocarpine in Qlosi single-use vials
1.44%aceclidine in VIZZ
750participants aged 40 to 55 in GEMINI 1 and 2
How they work
A smaller pupil, a deeper focus
They do not replace reading glasses for everyone, but for the right patient they add a new conversation to the routine exam, in optometry and ophthalmology practices alike.
Each drop is a cholinergic agonist that constricts the pupil, creating a pinhole effect that improves near and intermediate vision. The products differ in strength, dosing and how much they affect the ciliary muscle.
Qlosi (pilocarpine 0.4%)
Orasis. Single-use vials; a second dose may follow 2 to 3 hours later, up to twice daily.
LabelVIZZ (aceclidine 1.44%)
LENZ. Once daily; described as pupil-selective, with onset within 30 minutes and effect up to 10 hours.
LENZWho it suits
Adults with presbyopia who want fewer reading glasses for everyday near tasks, after a retinal exam.
LabelFitting drops into the exam
Presbyopia drops start with the same history and refraction you already do.
- Retinal exam before starting
- Set expectations on lighting
- Keep readers for long near work
-
Retina first
The Vuity label advises examining the retina in all patients before therapy because of rare retinal tears and detachments with miotics.
-
Dim light
Patients should not drive if vision is not clear, and should be cautious with night driving and poorly lit tasks.
-
Contact lenses
Vuity labeling calls for removing lenses before dosing and waiting 10 minutes to reinsert.
-
Common side effects
Vuity: headache, conjunctival hyperemia and eye irritation above 5%. Qlosi: instillation-site pain and headache in 5% to 8%. VIZZ: instillation irritation 20%, dim vision 16%, headache 13%.
Treatment paths
Every path for presbyopia
Presbyopia can be corrected with glasses, contact lenses, medication or surgery. Vision Rescue does not rank these paths; the eye doctor and the patient choose.
Reading glasses
Readers for close-up tasks, with the power set by an eye exam.
Optometrists and ophthalmologistsMultifocal glasses
Bifocal, trifocal or progressive lenses for patients who already wear glasses.
Optometrists and ophthalmologistsContact lenses
Monovision or multifocal contact lenses.
Optometrists and ophthalmologistsPresbyopia drops
Pilocarpine or aceclidine drops that reduce pupil size, used every day.
Prescribed by ODs and MDs within state scopeSurgery
Laser monovision or refractive lens exchange with lens implants.
Ophthalmic surgeons, with co-managing ODsIn the clinic
From conversation to prescription
A short script helps patients decide whether a drop fits their day.
Screen
Ask about near tasks, lighting and hobbies, and check the dilated retina for risk factors.
Choose
Match the product to dosing preference and how long the patient needs near vision each day.
Follow up
Review comfort, night vision and satisfaction at the first check, and adjust or stop as needed.
Label details
Products at a glance
| Vuity (AbbVie) | Pilocarpine HCl 1.25%; once daily, optional second dose 3 to 6 hours later |
|---|---|
| Qlosi (Orasis) | Pilocarpine 0.4% single-use vials; repeat after 2 to 3 hours, up to twice daily; effect up to 8 hours |
| VIZZ (LENZ) | Aceclidine 1.44%; once daily; approval announced July 31, 2025 |
Vuity warnings and precautions
- Blurred vision; caution with night driving and poor illumination
- Rare retinal detachment and retinal tear with miotics; retinal exam advised before starting
- Caution in patients with iritis
- Remove contact lenses and wait 10 minutes after dosing
VIZZ trials
LENZ reported results from CLARITY 1 and 2, with 466 participants, and the CLARITY 3 safety study, with 217 participants.
Questions about presbyopia drops
Who is a candidate?
Adults with presbyopia who want less reliance on reading glasses, after a retinal examination.
How long do the drops last?
Qlosi lists effect up to 8 hours and LENZ cites up to 10 hours for VIZZ. Vuity allows a second daily dose 3 to 6 hours after the first.
What are the most common side effects?
Headache and eye redness or irritation for pilocarpine products; instillation irritation, dim vision and headache for VIZZ.
Can patients drive at night?
Patients should not drive if vision is not clear and should take care in low light.
Are generic pilocarpine drops the same?
No. Generic pilocarpine 1% to 4% is a glaucoma medicine, not a presbyopia product.
Where are they dispensed?
Through retail pharmacies on prescription. They are not stocked by Vision Rescue.
References
- VUITY (pilocarpine HCl ophthalmic solution) 1.25% Prescribing Information, AbbVie, 2023. Label
- QLOSI (pilocarpine HCl ophthalmic solution) 0.4% Prescribing Information. Label
- LENZ Therapeutics. FDA approval of VIZZ for the treatment of presbyopia, July 31, 2025. LENZ
- American Academy of Ophthalmology. Presbyopia treatment. AAO
Add presbyopia drops to the conversation
Offer patients one more option for near vision, alongside readers, multifocals, contact lenses and surgery, in optometry and ophthalmology practices alike.
Stay current: Latest eye care industry news
Written for licensed eye care professionals. Vuity, Qlosi and VIZZ are trademarks of their owners. Review the full Prescribing Information before prescribing. Prescriptions are excluded from the RescueLink participation credit.